Reading: CHP 6 Acid Base Theories: Sect 6.1, 6.2, 6.3 (intro), 6.4.0-6.4.2, 6.6

PreAssignment:

Learning Outcomes:

  1. know the 4 common definitions of acids and bases be able describe a substance as an acid or base according to one or more of the common definitions
  2. be able to identify conjugate acids and bases (Br├śnsted-Lowry)
  3. describe the interactions of metals and ligands: donors and acceptors
  4. know the definition of frontier orbitals predict the likelihood of a Lewis acid base interaction from a MO approach
  5. use HSAB theory to predict the strength of interactions between Lewis acids (metals) and Lewis bases (ligands)

Group Activity - Acid base theories - POGIL worksheet


Problem Set (4th Ed): 6.1, 6.2, 6.3, 6.4, 6.8, ne,  ne,  ne,   6.13, 6.14, 6.18, 6.25, 6.26 (solutions)

Problem Set (5th Ed): 6.1, 6.2, 6.3, 6.4, 6.5, 6.7, 6.9, 6.11, 6.20, 6.21, 6.25, 6.32, 6.34 (solutions)
(Note: 6.1 and 6.2 have new examples in the 5th ed,  ne = no equivalent problem)

 

Reading: CHP 6 Acid Base Strength: Sect 6.3 (all), 6.4 (all)

PreAssignment:

  • Read section 6.4 carefully

Learning Outcomes:

  1. Know definition of proton affinity as a measure of acid-base strength
  2. Know trend in acid-base strength of binary hydrogen compounds
  3. Use inductive effects, oxyanion strength, cation acidity, and steric effects to predict trends in acid-base strength between acids or bases of similar structure
  4. Understand the effect of solvation of the strength of an acid or base

Group Activity - Acid base Strength - POGIL worksheet


Problem Set (4th Ed): 6.27, 6.29, 6.30, 6.31, 6.32, 6.33 (solutions)

Problem Set (5th Ed): 6.34, 6.36, 6.37, 6.38, 6.39, 6.40 (solutions)

Paper 1: Page and Badarau, The Mechanisms of Catalysis by Metallo ╬▓-Lactamases, Bioinorganic Chemistry and Applications, 2008

Paper 2: Zastrow and Pecoraro, Designing Hydrolytic Zinc Metalloenzymes, 2014Designing Hydrolytic Zinc Metalloenzymes, 2014

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